KBbox: Methods

Introduction

Create kinetic models using ordinary differential equations

ODE models can, for example, be used to predict how plasma levels of a drug change with time following dose.

Computational Tools

ODE modelling can be performed using the following software tools:

Berkeley Madonna

Example Cases

For examples of previously performed studies in which ODE modelling was the primary method used, see the following example cases:

Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat.

Tutorials

The folowing tutorial describes the use of ODE modelling:

Compartmental modelling and simulation in Berkeley Madonna