PKPD modeling (pharmacokinetic/pharmacodynamic modeling) is a technique that combines the two classical pharmacological disciplines of pharmacokinetics and pharmacodynamics. It integrates a pharmacokinetic and a pharmacodynamic model component into one set of mathematical expressions that allows the description of the time course of effect intensity in response to administration of a drug dose.

There are a variety of PKPD modeling approaches, but there are only five major classes:

  • Direct link PKPD models
  • Indirect link PKPD models
  • Indirect response PKPD models
  • Cell Lifespan models
  • Complex response models